Funded by The National Institute of Biomedical Imaging and Bioengineering

CBM² Tool Development for Precision Medicine

We are producing a suite of mixed-scale devices (i.e., task-specific modules) that can be integrated into a fluidic motherboard to produce systems, which can process liquid biopsy samples, for a broad range of clinical applications with a Precision Medicine focus. The attributes of our systems are:

•Devices made from thermoplastics via injection molding with mixed-scales structures (mm → nm)

•Extensive infrastructure for making and characterizing device architecture and material properties

•Ability to change the surface chemistry of the plastic to match the application (covalent attachment of biologics, alter surface wettability, etc.).

•Toolbox of devices for the selection of liquid biopsy markers from clinical samples (blood, saliva, urine, etc.)

•Label-free and single-molecule analysis device (X-ToF) for determining the molecular structure of biopolymers, such as DNA, RNA, and proteins.

•Modular systems with an automated workflow to accept a clinical sample, enrich the required liquid biopsy marker, and secure molecular information on even low abundant markers.

•Ability of integrated system to search of epigenetic, epitranscriptomic, and post-translational modifications in DNA, RNA, and proteins, respectively.