Publications

Publications by Year

  1. Rashid A, Wesson W, Abdallah AO, Snyder J, Venkatesh P, Mushtaq MU, Shune L, Witek MA, McGuirk JP, Soper SA, Cui W, Ahmed N. BCMA-Directed MRD Detection as a Predictor of Relapse after BCMA CAR T in Multiple Myeloma. Clin Lymphoma Myeloma Leuk. 2025 Jan;25(1):52-57. doi: 10.1016/j.clml.2024.10.003. Epub 2024 Oct 11. PMID: 39516088.
  2. Chibuike M, Rathnayaka C, Shivanka S, Choi J, Verber M, Park S, Soper SA. Millisecond Label-Free Single Peptide Detection and Identification Using Nanoscale Electrochromatography and Resistive Pulse Sensing. Anal Chem. 2025 Jan 14;97(1):427-435. doi: 10.1021/acs.analchem.4c04542. Epub 2024 Dec 23. PMID: 39713813.
  3. Michaut A, Mongera A, Gupta A, Tarazona OA, Serra M, Kefala GM, Rigoni P, Lee JG, Rivas F, Hall AR, Mahadevan L, Guevorkian K, Pourquié O. Extracellular volume expansion drives vertebrate axis elongation. Curr Biol. 2025 Feb 24;35(4):843-853.e6. doi: 10.1016/j.cub.2024.12.051. Epub 2025 Jan 28. PMID: 39879975. 
  4. Hyler AR, Thomas DE, Kinskie KS, Brown KM, Duncan JL, Cemazar J, Schultz J, Brown S, Shiri F, Soper SA, Swami NS, Davalos RV. Characterizing Recent PDMS Changes in Electrokinetic-Based Microfluidic Devices' Performance and Manufacturing for Cell Sorting Applications. Electrophoresis. 2025 Feb 18. doi: 10.1002/elps.8113. Epub ahead of print. PMID: 39965072.
  5. Deri Morgan, Dakota DD Okuwuone, Kiersten L Berggren, Alyssa Schmidt, Colby Spiess, Hannah Smith, Ravi Yada, Nathan Hendrikse, Rashna Madan, Devin Shrock, Chris Lominska, Mengjia Hu, Malgorzata A. Witek, Steven A. Soper, Yuting Lin, Hao Gao, Dennis J McCance, Sufi M Thomas, David Beebe, Sheena Kerr, Gregory N Gan. MK2 promotes p16 negative head and neck cancer migration, invasion, and metastasis. Cancer Letters, 2025, accepted.
  1. Rayamajhi S, Sipes J, Tetlow AL, Saha S, Bansal A, Godwin AK. Extracellular Vesicles as Liquid Biopsy Biomarkers across the Cancer Journey: From Early Detection to Recurrence. Clin Chem. 2024 Jan 4;70(1):206-219. doi: 10.1093/clinchem/hvad176. PMID: 38175602.
  2. Erxleben DA, Dodd RJ, Day AJ, Green DE, DeAngelis PL, Poddar S, Enghild JJ, Huebner JL, Kraus VB, Watkins AR, Reesink HL, Rahbar E, Hall AR. Targeted Analysis of the Size Distribution of Heavy Chain-Modified Hyaluronan with Solid-State Nanopores. Anal Chem. 2024 Jan 30;96(4):1606-1613. doi: 10.1021/acs.analchem.3c04387. Epub 2024 Jan 12. PMID: 38215004; PMCID: PMC11037269.
  3. Sharma P, Stecklein SR, Yoder R, Staley JM, Schwensen K, O'Dea A, Nye L, Satelli D, Crane G, Madan R, O'Neil MF, Wagner J, Larson KE, Balanoff C, Kilgore L, Phadnis MA, Godwin AK, Salgado R, Khan QJ, O'Shaughnessy J. Clinical and Biomarker Findings of Neoadjuvant Pembrolizumab and Carboplatin Plus Docetaxel in Triple-Negative Breast Cancer: NeoPACT Phase 2 Clinical Trial. JAMA Oncol. 2024 Feb 1;10(2):227-235. doi: 10.1001/jamaoncol.2023.5033. PMID: 37991778; PMCID: PMC10666040.
  4. Saeed A, Park R, Pathak H, Al-Bzour AN, Dai J, Phadnis M, Al-Rajabi R, Kasi A, Baranda J, Sun W, Williamson S, Chiu YC, Osmanbeyoglu HU, Madan R, Abushukair H, Mulvaney K, Godwin AK, Saeed A. Clinical and biomarker results from a phase II trial of combined cabozantinib and durvalumab in patients with chemotherapy-refractory colorectal cancer (CRC): CAMILLA CRC cohort. Nat Commun. 2024 Feb 20;15(1):1533. doi: 10.1038/s41467-024-45960-2. PMID: 38378868; PMCID: PMC10879200.
  5. Wang S, Ok JT, Park S, Elsharafi M, Guo Y. A Simplified Model for the Study of Film-Boiling Droplet Motion on Microscale Ratchets. Appl Mech (Basel). 2024 Mar;5(1):91-101. doi: 10.3390/applmech5010006. Epub 2024 Jan 30. PMID: 39170914; PMCID: PMC11336455.
  6. Abu Jalboush S, Wadsworth ID, Sethi K, Rogers LC, Hollis T, Hall AR. Improving the Performance of Selective Solid-State Nanopore Sensing Using a Polyhistidine-Tagged Monovalent Streptavidin. ACS Sens. 2024 Mar 22;9(3):1602-1610. doi: 10.1021/acssensors.4c00200. Epub 2024 Mar 7. PMID: 38451864; PMCID: PMC11056946.
  7. Pulliam L, Sun B, McCafferty E, Soper SA, Witek MA, Hu M, Ford JM, Song S, Kapogiannis D, Glesby MJ, Merenstein D, Tien PC, Freasier H, French A, McKay H, Diaz MM, Ofotokun I, Lake JE, Margolick JB, Kim EY, Levine SR, Fischl MA, Li W, Martinson J, Tang N. Microfluidic Isolation of Neuronal-Enriched Extracellular Vesicles Shows Distinct and Common Neurological Proteins in Long COVID, HIV Infection and Alzheimer's Disease. Int J Mol Sci. 2024 Mar 29;25(7):3830. doi: 10.3390/ijms25073830. PMID: 38612641; PMCID: PMC11011771.
  8. Rathnayaka C, Chandrosoma IA, Choi J, Childers K, Chibuike M, Akabirov K, Shiri F, Hall AR, Lee M, McKinney C, Verber M, Park S, Soper SA. Detection and identification of single ribonucleotide monophosphates using a dual in-plane nanopore sensor made in a thermoplastic via replication. Lab Chip. 2024 May 14;24(10):2721-2735. doi: 10.1039/d3lc01062g. PMID: 38656267; PMCID: PMC11091956.
  9. Martín M, Yoder R, Salgado R, Del Monte-Millán M, Álvarez EL, Echavarría I, Staley JM, O'Dea AP, Nye LE, Stecklein SR, Bueno C, Jerez Y, Cebollero M, Bueno O, García Saenz JÁ, Moreno F, Bohn U, Gómez H, Massarrah T, Khan QJ, Godwin AK, López-Tarruella S, Sharma P. Tumor-Infiltrating Lymphocytes Refine Outcomes in Triple-Negative Breast Cancer Treated with Anthracycline-Free Neoadjuvant Chemotherapy. Clin Cancer Res. 2024 May 15;30(10):2160-2169. doi: 10.1158/1078-0432.CCR-24-0106. PMID: 38466643; PMCID: PMC11096004.
  10. Park J, Xu J, Engler A, Williamson J, Mathew V, Park S, Flake J. Extending Copper Interconnects and Epoxy Dielectrics to Multi-GHz Frequencies. IEEE Trans Compon Packaging Manuf Technol. 2024 Jun;14(6):984-992. doi: 10.1109/tcpmt.2024.3399662. Epub 2024 May 9. PMID: 39309372; PMCID: PMC11412072.
  11. Childers K, Freed IM, Hupert ML, Shaw B, Larsen N, Herring P, Norton JH, Shiri F, Vun J, August KJ, Witek MA, Soper SA. Novel thermoplastic microvalves based on an elastomeric cyclic olefin copolymer. Lab Chip. 2024 Sep 10;24(18):4422-4439. doi: 10.1039/d4lc00501e. PMID: 39171671; PMCID: PMC11339931.
  12. Witek MA, Larkey NE, Bartakova A, Hupert ML, Mog S, Cronin JK, Vun J, August KJ, Soper SA. Microfluidic Affinity Selection of B-Lineage Cells from Peripheral Blood for Minimal Residual Disease Monitoring in Pediatric B-Type Acute Lymphoblastic Leukemia Patients. Int J Mol Sci. 2024 Oct 2;25(19):10619. doi: 10.3390/ijms251910619. PMID: 39408948; PMCID: PMC11477226.
  13. Erxleben DA, Rivas F, Smith I, Poddar S, DeAngelis PL, Rahbar E, Hall AR. High-fidelity and iterative affinity extraction of hyaluronan. Proteoglycan Res. 2024 Oct-Dec;2(4):e70008. doi: 10.1002/pgr2.70008. Epub 2024 Dec 6. PMID: 39650564; PMCID: PMC11623434.
  1. Hu M, Brown V, Jackson JM, Wijerathne H, Pathak H, Koestler DC, Nissen E, Hupert ML, Muller R, Godwin AK, Witek MA, Soper SA. Assessing Breast Cancer Molecular Subtypes Using Extracellular Vesicles' mRNA. Anal Chem. 2023 May 16;95(19):7665-7675. doi: 10.1021/acs.analchem.3c00624. Epub 2023 Apr 18. PMID: 37071799; PMCID: PMC10243595.
  2. Witek MA, Soper SA, Godwin AK. Changing the Paradigm in Prognostic Breast Cancer Testing Based on Extracellular Vesicles. Res J Biol. 2023 Jun;11(2):23-25. Epub 2023 Jun 22. PMID: 38933497; PMCID: PMC11208111.
  3. Vaidyanathan S, Wijerathne H, Gamage SST, Shiri F, Zhao Z, Choi J, Park S, Witek MA, McKinney C, Verber M, Hall AR, Childers K, McNickle T, Mog S, Yeh E, Godwin AK, Soper SA. High Sensitivity Extended Nano-Coulter Counter for Detection of Viral Particles and Extracellular Vesicles. Anal Chem. 2023 Jul 4;95(26):9892-9900. doi: 10.1021/acs.analchem.3c00855. Epub 2023 Jun 19. PMID: 37336762; PMCID: PMC11015478.
  4. Freed IM, Kasi A, Fateru O, Hu M, Gonzalez P, Weatherington N, Pathak H, Hyter S, Sun W, Al-Rajabi R, Baranda J, Hupert ML, Chalise P, Godwin AK, A Witek M, Soper SA. Circulating Tumor Cell Subpopulations Predict Treatment Outcome in Pancreatic Ductal Adenocarcinoma (PDAC) Patients. Cells. 2023 Sep 13;12(18):2266. doi: 10.3390/cells12182266. PMID: 37759489; PMCID: PMC10526802.
  5. Babayev E, Suebthawinkul C, Gokyer D, Parkes WS, Rivas F, Pavone ME, Hall AR, Pritchard MT, Duncan FE. Cumulus expansion is impaired with advanced reproductive age due to loss of matrix integrity and reduced hyaluronan. Aging Cell. 2023 Nov;22(11):e14004. doi: 10.1111/acel.14004. Epub 2023 Oct 18. PMID: 37850336; PMCID: PMC10652338.
  6. Shiri F, Choi J, Vietz C, Rathnayaka C, Manoharan A, Shivanka S, Li G, Yu C, Murphy MC, Soper SA, Park S. Nano-injection molding with resin mold inserts for prototyping of nanofluidic devices for single molecular detection. Lab Chip. 2023 Nov 7;23(22):4876-4887. doi: 10.1039/d3lc00543g. PMID: 37870483; PMCID: PMC10995647.
  7. de Jong IEM, Hunt ML, Chen D, Du Y, Llewellyn J, Gupta K, Li D, Erxleben D, Rivas F, Hall AR, Furth EE, Naji A, Liu C, Dhand A, Burdick JA, Davey MG, Flake AW, Porte RJ, Russo PA, Gaynor JW, Wells RG. A fetal wound healing program after intrauterine bile duct injury may contribute to biliary atresia. J Hepatol. 2023 Dec;79(6):1396-1407. doi: 10.1016/j.jhep.2023.08.010. Epub 2023 Aug 21. PMID: 37611641; PMCID: PMC10841314.
  8. Wu J, Choi J, Uba FI, Soper SA, Park S. Engineering inlet structures to enhance DNA capture into nanochannels in a polymer nanofluidic device produced via nanoimprint lithography. Micro Nano Eng. 2023 Dec;21:100230. doi: 10.1016/j.mne.2023.100230. Epub 2023 Oct 6. PMID: 38737190; PMCID: PMC11085012.
  1. Rivas F, DeAngelis PL, Rahbar E, Hall AR. Optimizing the sensitivity and resolution of hyaluronan analysis with solid-state nanopores. Sci Rep. 2022 Mar 16;12(1):4469. doi: 10.1038/s41598-022-08533-1. PMID: 35296752; PMCID: PMC8927330. 
  2. Rivas F, Erxleben D, Smith I, Rahbar E, DeAngelis PL, Cowman MK, Hall AR. Methods for isolating and analyzing physiological hyaluronan: a review. Am J Physiol Cell Physiol. 2022 Apr 1;322(4):C674-C687. doi: 10.1152/ajpcell.00019.2022. Epub 2022 Feb 23. PMID: 35196167; PMCID: PMC8977137.
  3. Zhao X, Ma C, Park DS, Soper SA, Murphy MC. Air bubble removal: Wettability contrast enabled microfluidic interconnects. Sens Actuators B Chem. 2022 Jun 15;361:131687. doi: 10.1016/j.snb.2022.131687. Epub 2022 Mar 12. PMID: 35611132; PMCID: PMC9124586.
  4. Vaidyanathan S, Gamage S, Dathathreya K, Kryk R, Manoharan A, Zhao Z, Zhang L, Choi J, Park D, Park S, Soper SA. Fluidic operation of a polymer-based nanosensor chip for analysing single molecules. Flow (Camb). 2022;2:E14. doi: 10.1017/flo.2022.8. Epub 2022 Jun 27. PMID: 35936867; PMCID: PMC9356744. 
  5. Jia Z, Choi J, Lee S, Soper SA, Park S. Modifying surface charge density of thermoplastic nanofluidic biosensors by multivalent cations within the slip plane of the electric double layer. Colloids Surf A Physicochem Eng Asp. 2022 Sep 5;648:129147. doi: 10.1016/j.colsurfa.2022.129147. Epub 2022 May 4. PMID: 36685784; PMCID: PMC9853209.
  6. Gamage SST, Pahattuge TN, Wijerathne H, Childers K, Vaidyanathan S, Athapattu US, Zhang L, Zhao Z, Hupert ML, Muller RM, Muller-Cohn J, Dickerson J, Dufek D, Geisbrecht BV, Pathak H, Pessetto Z, Gan GN, Choi J, Park S, Godwin AK, Witek MA, Soper SA. Microfluidic affinity selection of active SARS-CoV-2 virus particles. Sci Adv. 2022 Sep 30;8(39):eabn9665. doi: 10.1126/sciadv.abn9665. Epub 2022 Sep 28. PMID: 36170362; PMCID: PMC9519043.
  7. Rathnayaka C, Amarasekara CA, Akabirov K, Murphy MC, Park S, Witek MA, Soper SA. Nanofluidic devices for the separation of biomolecules. J Chromatogr A. 2022 Nov 8;1683:463539. doi: 10.1016/j.chroma.2022.463539. Epub 2022 Sep 30. PMID: 36223665; PMCID: PMC9795076.
  8. Zhao Z, Vaidyanathan S, Bhanja P, Gamage S, Saha S, McKinney C, Choi J, Park S, Pahattuge T, Wijerathne H, Jackson JM, Huppert ML, Witek MA, Soper SA. In-plane Extended Nano-coulter Counter (XnCC) for the Label-free Electrical Detection of Biological Particles. Electroanalysis. 2022 Dec;34(12):1961-1975. doi: 10.1002/elan.202200091. Epub 2022 Jun 14. PMID: 37539083; PMCID: PMC10399599.
  1. Zhao Z, Wijerathne H, Godwin AK, Soper SA. Isolation and analysis methods of extracellular vesicles (EVs). Extracell Vesicles Circ Nucl Acids. 2021;2(1):80-103. doi: 10.20517/evcna.2021.07. Epub 2020 Mar 30. Erratum in: Extracell Vesicles Circ Nucl Acids. 2021 Sep 15;2(3):222-223. doi: 10.20517/evcna.2021.15. PMID: 34414401; PMCID: PMC8372011.
  2. Amarasekara CA, Rathnayaka C, Athapattu US, Zhang L, Choi J, Park S, Nagel AC, Soper SA. Electrokinetic identification of ribonucleotide monophosphates (rNMPs) using thermoplastic nanochannels. J Chromatogr A. 2021 Feb 8;1638:461892. doi: 10.1016/j.chroma.2021.461892. Epub 2021 Jan 8. PMID: 33477027; PMCID: PMC8107831.
  3. Zhao X, Park DS, Choi J, Park S, Soper SA, Murphy MC. Flexible-templated imprinting for fluorine-free, omniphobic plastics with re-entrant structures. J Colloid Interface Sci. 2021 Mar;585:668-675. doi: 10.1016/j.jcis.2020.10.046. Epub 2020 Oct 20. PMID: 33127056; PMCID: PMC8483707.
  4. Athapattu US, Amarasekara CA, Immel JR, Bloom S, Barany F, Nagel AC, Soper SA. Solid-phase XRN1 reactions for RNA cleavage: application in single-molecule sequencing. Nucleic Acids Res. 2021 Apr 19;49(7):e41. doi: 10.1093/nar/gkab001. PMID: 33511416; PMCID: PMC8053086.
  5. Vaidyanathan S, Weerakoon-Ratnayake KM, Uba FI, Hu B, Kaufman D, Choi J, Park S, Soper SA. Thermoplastic nanofluidic devices for identifying abasic sites in single DNA molecules. Lab Chip. 2021 Apr 20;21(8):1579-1589. doi: 10.1039/d0lc01038c. PMID: 33651049; PMCID: PMC8293902.
  6. Pahattuge TN, Freed IM, Hupert ML, Vaidyanathan S, Childers K, Witek MA, Weerakoon-Ratnayake K, Park D, Kasi A, Al-Kasspooles MF, Murphy MC, Soper SA. System Modularity Chip for Analysis of Rare Targets (SMART-Chip): Liquid Biopsy Samples. ACS Sens. 2021 May 28;6(5):1831-1839. doi: 10.1021/acssensors.0c02728. Epub 2021 May 3. PMID: 33938745; PMCID: PMC8325110.
  7. Campos CDM, Childers K, Gamage SST, Wijerathne H, Zhao Z, Soper SA. Analytical Technologies for Liquid Biopsy of Subcellular Materials. Annu Rev Anal Chem (Palo Alto Calif). 2021 Jul 27;14(1):207-229. doi: 10.1146/annurev-anchem-091520-093931. PMID: 33974805; PMCID: PMC8601690.
  8. Athapattu US, Rathnayaka C, Vaidyanathan S, Gamage SST, Choi J, Riahipour R, Manoharan A, Hall AR, Park S, Soper SA. Tailoring Thermoplastic In-Plane Nanopore Size by Thermal Fusion Bonding for the Analysis of Single Molecules. ACS Sens. 2021 Aug 27;6(8):3133-3143. doi: 10.1021/acssensors.1c01359. Epub 2021 Aug 18. PMID: 34406743; PMCID: PMC8482307.
  9. Brown CR, Zhao X, Park T, Chen PC, You BH, Park DS, Soper SA, Baird A, Murphy MC. Leakage pressures for gasketless superhydrophobic fluid interconnects for modular lab-on-a-chip systems. Microsyst Nanoeng. 2021 Sep 2;7:69. doi: 10.1038/s41378-021-00287-6. PMID: 34567781; PMCID: PMC8433346.
  10. Zhao X, Murphy MC. A High-adhesion Binding Strategy for Silica Nanoparticle-based Superhydrophobic Coatings. Colloids Surf A Physicochem Eng Asp. 2021 Sep 20;625:126810. doi: 10.1016/j.colsurfa.2021.126810. Epub 2021 May 11. PMID: 35221533; PMCID: PMC8880838.
  11. Choi J, Jia Z, Riahipour R, McKinney CJ, Amarasekara CA, Weerakoon-Ratnayake KM, Soper SA, Park S. Label-Free Identification of Single Mononucleotides by Nanoscale Electrophoresis. Small. 2021 Oct;17(42):e2102567. doi: 10.1002/smll.202102567. Epub 2021 Sep 23. PMID: 34558175; PMCID: PMC8542607.

Liquid Biopsy

  1. Pahattuge TN, Jackson JM, Digamber R, Wijerathne H, Brown V, Witek MA, Perera C, Givens RS, Peterson BR, Soper SA. Visible photorelease of liquid biopsy markers following microfluidic affinity-enrichment. Chem Commun (Camb). 2020 Apr 14;56(29):4098-4101. doi: 10.1039/c9cc09598e. Epub 2020 Mar 12. PMID: 32163053; PMCID: PMC7469076.
  2. Ruiz C, Huang J, Giardina SF, Feinberg PB, Mirza AH, Bacolod MD, Soper SA, Barany F. Single-molecule detection of cancer mutations using a novel PCR-LDR-qPCR assay. Hum Mutat. 2020 May;41(5):1051-1068. doi: 10.1002/humu.23987. Epub 2020 Feb 17. Erratum in: Hum Mutat. 2021 Sep;42(9):1184. doi: 10.1002/humu.24254. PMID: 31950578; PMCID: PMC7160051.
  3. Bacolod MD, Mirza AH, Huang J, Giardina SF, Feinberg PB, Soper SA, Barany F. Application of Multiplex Bisulfite PCR-Ligase Detection Reaction-Real-Time Quantitative PCR Assay in Interrogating Bioinformatically Identified, Blood-Based Methylation Markers for Colorectal Cancer. J Mol Diagn. 2020 Jul;22(7):885-900. doi: 10.1016/j.jmoldx.2020.03.009. Epub 2020 May 12. PMID: 32407802; PMCID: PMC7338890.
  4. Park DS, Young BM, You BH, Singh V, Soper SA, Murphy MC. An integrated, optofluidic system with aligned optical waveguides, microlenses, and coupling prisms for fluorescence sensing. J Microelectromech Syst. 2020 Aug;29(4):600-609. doi: 10.1109/jmems.2020.3004374. Epub 2020 Jul 2. PMID: 39391841; PMCID: PMC11465942.
  5. Wijerathne H, Witek MA, Baird AE, Soper SA. Liquid biopsy markers for stroke diagnosis. Expert Rev Mol Diagn. 2020 Aug;20(8):771-788. doi: 10.1080/14737159.2020.1777859. Epub 2020 Jul 5. PMID: 32500751; PMCID: PMC8157911.

Extracellular Vesicle (EV) Isolation

  1. Trinidad CV, Tetlow AL, Bantis LE, Godwin AK. Reducing Ovarian Cancer Mortality Through Early Detection: Approaches Using Circulating Biomarkers. Cancer Prev Res (Phila). 2020 Mar;13(3):241-252. doi: 10.1158/1940-6207.CAPR-19-0184. PMID: 32132118; PMCID: PMC7080297.
  2. Wijerathne H, Witek MA, Jackson JM, Brown V, Hupert ML, Herrera K, Kramer C, Davidow AE, Li Y, Baird AE, Murphy MC, Soper SA. Affinity enrichment of extracellular vesicles from plasma reveals mRNA changes associated with acute ischemic stroke. Commun Biol. 2020 Oct 26;3(1):613. doi: 10.1038/s42003-020-01336-y. PMID: 33106557; PMCID: PMC7589468.

Rare Cell Isolation References

  1. Witek MA, Freed IM, Soper SA. Cell Separations and Sorting. Anal Chem. 2020 Jan 7;92(1):105-131. doi: 10.1021/acs.analchem.9b05357. Epub 2019 Dec 20. PMID: 31808677; PMCID: PMC7469080.
  2. M Weerakoon-Ratnayake K, Vaidyanathan S, Larky N, Dathathreya K, Hu M, Jose J, Mog S, August K, K Godwin A, L Hupert M, A Witek M, A Soper S. Microfluidic Device for On-Chip Immunophenotyping and Cytogenetic Analysis of Rare Biological Cells. Cells. 2020 Feb 24;9(2):519. doi: 10.3390/cells9020519. PMID: 32102446; PMCID: PMC7072755.

Plastic Fabrication

  1. Bacolod MD, Huang J, Giardina SF, Feinberg PB, Mirza AH, Swistel A, Soper SA, Barany F. Prediction of blood-based biomarkers and subsequent design of bisulfite PCR-LDR-qPCR assay for breast cancer detection. BMC Cancer. 2020 Jan 31;20(1):85. doi: 10.1186/s12885-020-6574-4. PMID: 32005108; PMCID: PMC6995062.
  2. Kong C, Hu M, Weerakoon-Ratnayake KM, Witek MA, Dathathreya K, Hupert ML, Soper SA. Label-free counting of affinity-enriched circulating tumor cells (CTCs) using a thermoplastic micro-Coulter counter (μCC). Analyst. 2020 Mar 2;145(5):1677-1686. doi: 10.1039/c9an01802f. PMID: 31867587; PMCID: PMC7350181.
  3. Zhang B, Dodaran MS, Shao S, Choi J, Park S, Meng WJ. Understanding of plasticity size-effect governed mechanical response and incomplete die filling in a microscale double-punch molding configuration. Int J Mech Sci. 2020 Apr 15;172:105406. doi: 10.1016/j.ijmecsci.2019.105406. Epub 2019 Dec 23. PMID: 34140747; PMCID: PMC8208638.
  4. Zhao X, Park DS, Choi J, Park S, Soper SA, Murphy MC. Robust, transparent, superhydrophobic coatings using novel hydrophobic/hydrophilic dual-sized silica particles. J Colloid Interface Sci. 2020 Aug 15;574:347-354. doi: 10.1016/j.jcis.2020.04.065. Epub 2020 Apr 18. PMID: 32335484; PMCID: PMC7256315.
  5. Zhao X, Park DS, Soper SA, Murphy MC. Microfluidic gasketless interconnects sealed by superhydrophobic surfaces. J Microelectromech Syst. 2020 Oct;29(5):894-899. doi: 10.1109/jmems.2020.3000325. Epub 2020 Jun 12. PMID: 33746475; PMCID: PMC7978084.
  6. Amarasekara CA, Athapattu US, Rathnayaka C, Choi J, Park S, Soper SA. Open-tubular nanoelectrochromatography (OT-NEC): gel-free separation of single stranded DNAs (ssDNAs) in thermoplastic nanochannels. Electrophoresis. 2020 Oct;41(18-19):1627-1640. doi: 10.1002/elps.202000109. Epub 2020 Aug 7. PMID: 33460211; PMCID: PMC8107830.

Other Publications

  1. Kaufman DG. The need for rapid therapeutic efficacy testing for cancer therapy. Exp Mol Pathol. 2020 Apr;113:104382. doi: 10.1016/j.yexmp.2020.104382. Epub 2020 Jan 23. PMID: 31982397; PMCID: PMC9261964.
  1. Prasad A, Choi J, Jia Z, Park S, Gartia MR. Nanohole array plasmonic biosensors: Emerging point-of-care applications. Biosens Bioelectron. 2019 Apr 1;130:185-203. doi: 10.1016/j.bios.2019.01.037. Epub 2019 Jan 24. PMID: 30738247; PMCID: PMC6475599.
  2. Hu W, Soper SA, Jackson JM. Time-Delayed Integration-Spectral Flow Cytometer (TDI-SFC) for Low-Abundance-Cell Immunophenotyping. Anal Chem. 2019 Apr 2;91(7):4656-4664. doi: 10.1021/acs.analchem.9b00021. Epub 2019 Mar 13. PMID: 30817129; PMCID: PMC6554645.
  3. Choi J, Lee CC, Park S. Scalable fabrication of sub-10 nm polymer nanopores for DNA analysis. Microsyst Nanoeng. 2019 Apr 8;5:12. doi: 10.1038/s41378-019-0050-9. PMID: 31057939; PMCID: PMC6453903.

Cell Free DNA (cfDNA), genomic DNA and RNA Isolation References

  1. Campos CDM, Gamage SST, Jackson JM, Witek MA, Park DS, Murphy MC, Godwin AK, Soper SA. Microfluidic-based solid phase extraction of cell free DNA. Lab Chip. 2018 Nov 6;18(22):3459-3470. doi: 10.1039/c8lc00716k. PMID: 30339164; PMCID: PMC6391159.

Rare Cell Isolation References

  1. Kamande JW, Lindell MAM, Witek MA, Voorhees PM, Soper SA. Isolation of circulating plasma cells from blood of patients diagnosed with clonal plasma cell disorders using cell selection microfluidics. Integr Biol (Camb). 2018 Feb 19;10(2):82-91. doi: 10.1039/c7ib00183e. PMID: 29372735; PMCID: PMC5877822.
  2. Campos CDM, Jackson JM, Witek MA, Soper SA. Molecular Profiling of Liquid Biopsy Samples for Precision Medicine. Cancer J. 2018 Mar/Apr;24(2):93-103. doi: 10.1097/PPO.0000000000000311. PMID: 29601336; PMCID: PMC5880307.

Plastic Fabrication

  1. Lee TY, Han K, Barrett DO, Park S, Soper SA, Murphy MC. Accurate, predictable, repeatable micro-assembly technology for polymer, microfluidic modules. Sens Actuators B Chem. 2018 Jan;254:1249-1258. doi: 10.1016/j.snb.2017.07.189. Epub 2017 Aug 2. PMID: 29531428; PMCID: PMC5844477.
  2. Jia Z, Choi J, Park S. Selection of UV-resins for nanostructured molds for thermal-NIL. Nanotechnology. 2018 Sep 7;29(36):365302. doi: 10.1088/1361-6528/aacd33. Epub 2018 Jun 18. PMID: 29911991; PMCID: PMC6532406.
  3. Choi J, Jia Z, Park S. Fabrication of polymeric dual-scale nanoimprint molds using a polymer stencil membrane. Microelectron Eng. 2018 Nov 5;199:101-105. doi: 10.1016/j.mee.2018.07.009. Epub 2018 Jul 19. PMID: 31011235; PMCID: PMC6474418.

Other Publications

  1. Beheshti M, Choi J, Geng X, Podlaha-Murphy E, Park S. Patterned electromagnetic alignment of magnetic nanowires. Microelectron Eng. 2018 Jun 5;193:71-78. doi: 10.1016/j.mee.2018.02.021. Epub 2018 Feb 21. PMID: 30270956; PMCID: PMC6159939.
  2. O'Neil C, Amarasekara CA, Weerakoon-Ratnayake KM, Gross B, Jia Z, Singh V, Park S, Soper SA. Electrokinetic transport properties of deoxynucleotide monophosphates (dNMPs) through thermoplastic nanochannels. Anal Chim Acta. 2018 Oct 16;1027:67-75. doi: 10.1016/j.aca.2018.04.047. Epub 2018 Apr 21. PMID: 29866271; PMCID: PMC6408931.
  3. Farshchian B, Pierce J, Beheshti MS, Park S, Kim N. Droplet Impinging Behavior on Surfaces with Wettability Contrasts. Microelectron Eng. 2018 Aug 5;195:50-56. doi: 10.1016/j.mee.2018.03.019. Epub 2018 Mar 20. PMID: 30270957; PMCID: PMC6159947.

Cell Free DNA (cfDNA), genomic DNA and RNA Isolation

  1. Im H, Lee S, Soper SA, Mitchell RJ. Staphylococcus aureus extracellular vesicles (EVs): surface-binding antagonists of biofilm formation. Mol Biosyst. 2017 Nov 21;13(12):2704-2714. doi: 10.1039/c7mb00365j. PMID: 29104975; PMCID: PMC5873579.

Rare Cell Isolation

  1. Materials and Microfluidics: Enabling the Efficient Isolation and Analysis of Circulating Tumour Cells, J.M. Jackson, M. Witek, J. Kamande and S.A. Soper, Chem. Soc. Rev. 46 (2017) 4245-4280.
  2. Witek MA, Aufforth RD, Wang H, Kamande JW, Jackson JM, Pullagurla SR, Hupert ML, Usary J, Wysham WZ, Hilliard D, Montgomery S, Bae-Jump V, Carey LA, Gehrig PA, Milowsky MI, Perou CM, Soper JT, Whang YE, Yeh JJ, Martin G, Soper SA. Discrete microfluidics for the isolation of circulating tumor cell subpopulations targeting fibroblast activation protein alpha and epithelial cell adhesion molecule. NPJ Precis Oncol. 2017;1:24. doi: 10.1038/s41698-017-0028-8. Epub 2017 Jul 25. PMID: 29657983; PMCID: PMC5871807.

Plastic Fabrication

  1. Amirsadeghi A, Brumfield L, Choi J, Brown E, Lee JJ, Park S. The role of hydrophobic silane coating on Si stamps in nanoimprint lithography. J Appl Phys. 2017 Jan 28;121(4):044909. doi: 10.1063/1.4974533. Epub 2017 Jan 31. PMID: 29632415; PMCID: PMC5881421.
  2. Weerakoon-Ratnayake KM, O'Neil CE, Uba FI, Soper SA. Thermoplastic nanofluidic devices for biomedical applications. Lab Chip. 2017 Jan 31;17(3):362-381. doi: 10.1039/c6lc01173j. PMID: 28009883; PMCID: PMC5285477.
  3. Farshchian B, Amirsadeghi A, Choi J, Park DS, Kim N, Park S. 3D nanomolding and fluid mixing in micromixers with micro-patterned microchannel walls. Nano Converg. 2017;4(1):4. doi: 10.1186/s40580-017-0098-x. Epub 2017 Mar 1. PMID: 28303213; PMCID: PMC5332510.
  4. Jackson JM, Witek MA, Kamande JW, Soper SA. Materials and microfluidics: enabling the efficient isolation and analysis of circulating tumour cells. Chem Soc Rev. 2017 Jul 17;46(14):4245-4280. doi: 10.1039/c7cs00016b. PMID: 28632258; PMCID: PMC5576189.

Rare Cell Isolation

  1. Jackson JM, Taylor JB, Witek MA, Hunsucker SA, Waugh JP, Fedoriw Y, Shea TC, Soper SA, Armistead PM. Microfluidics for the detection of minimal residual disease in acute myeloid leukemia patients using circulating leukemic cells selected from blood. Analyst. 2016 Jan 21;141(2):640-51. doi: 10.1039/c5an01836f. PMID: 26523411; PMCID: PMC4701594.
  2. Weerakoon-Ratnayake KM, Uba FI, Oliver-Calixte NJ, Soper SA. Electrophoretic Separation of Single Particles Using Nanoscale Thermoplastic Columns. Anal Chem. 2016 Apr 5;88(7):3569-77. doi: 10.1021/acs.analchem.5b04065. Epub 2016 Mar 22. PMID: 26963496; PMCID: PMC5555359.

Plastic Fabrication

  1. O’Neil CE, Jackson JM, Shim SH, Soper SA. Interrogating Surface Functional Group Heterogeneity of Activated Thermoplastics Using Super-Resolution Fluorescence Microscopy. Anal Chem. 2016 Apr 5;88(7):3686-96. doi: 10.1021/acs.analchem.5b04472. Epub 2016 Mar 11. PMID: 26927303; PMCID: PMC5546217.
  2. O'Neil CE, Taylor S, Ratnayake K, Pullagurla S, Singh V, Soper SA. Characterization of activated cyclic olefin copolymer: effects of ethylene/norbornene content on the physiochemical properties. Analyst. 2016 Nov 28;141(24):6521-6532. doi: 10.1039/c6an01448h. PMID: 27827488; PMCID: PMC5354357.

Other Publications

  1. Soper SA, Rasooly A. Cancer: a global concern that demands new detection technologies. Analyst. 2016 Jan 21;141(2):367-70. doi: 10.1039/c5an90101d. PMID: 26688866; PMCID: PMC4777894.
  2. Ok JT, Choi J, Brown E, Park S. Effect of Different Fluids on Rectified Motion of Leidenfrost Droplets on Micro/Sub-Micron Ratchets. Microelectron Eng. 2016 Jun 1;158:130-134. doi: 10.1016/j.mee.2016.04.018. Epub 2016 Apr 24. PMID: 27721527; PMCID: PMC5053398.

Rare Cell Isolation

  1. Nair SV, Witek MA, Jackson JM, Lindell MA, Hunsucker SA, Sapp T, Perry CE, Hupert ML, Bae-Jump V, Gehrig PA, Wysham WZ, Armistead PM, Voorhees P, Soper SA. Enzymatic cleavage of uracil-containing single-stranded DNA linkers for the efficient release of affinity-selected circulating tumor cells. Chem Commun (Camb). 2015 Feb 21;51(15):3266-9. doi: 10.1039/c4cc09765c. PMID: 25616078; PMCID: PMC4552044.

Plastic Fabrication

  1. Uba FI, Pullagurla SR, Sirasunthorn N, Wu J, Park S, Chantiwas R, Cho YK, Shin H, Soper SA. Surface charge, electroosmotic flow and DNA extension in chemically modified thermoplastic nanoslits and nanochannels. Analyst. 2015 Jan 7;140(1):113-26. doi: 10.1039/c4an01439a. PMID: 25369728; PMCID: PMC4280799.
  2. Uba FI, Hu B, Weerakoon-Ratnayake K, Oliver-Calixte N, Soper SA. High process yield rates of thermoplastic nanofluidic devices using a hybrid thermal assembly technique. Lab Chip. 2015 Feb 21;15(4):1038-49. doi: 10.1039/c4lc01254b. PMID: 25511610; PMCID: PMC4315742.
  3. You BH, Park DS, Rani SD, Murphy MC. Assembly of Polymer Microfluidic Components and Modules: Validating Models of Passive Alignment Accuracy. J Microelectromech Syst. 2015 Jun;24(3):634-650. doi: 10.1109/JMEMS.2014.2339733. Epub 2014 Aug 1. PMID: 31814689; PMCID: PMC6897507.