Past and Current Projects
Collaborative Projects
Table 1. NEW Collaborative Projects for Phase 3.
Project Title | Affiliations |
Patrick Fromal; Modular Mixed-Scale Systems for Detecting and Identifying Low Abundant Proteins from Clinical Samples | Shimadzu Corporation; Columbia, MD |
Daniel Chiu; Extracellular RNA Carrier Subclasses in Processes Relevant to Substance use Disorders or HIV Infection; | University of Washington, Seattle, WA |
Stefanie Saupe; Patterning Ag/AgCl thin metal films on plastics for Resistive Pulse Sensing (RPS) | Natech Plastics Inc., Ronkonkoma, NY |
Susan Lunte; COBRE: Molecular Analysis of Disease Pathways; National Institutes of Health; | University of Kansas, Lawrence, KS; |
Mark Oldakowski; Integrated and Modular System for Sequencing DNA/RNA from Liquid Biopsy Samples | Bionano; San Diego, CA |
Joanna Burdette (PI); Dynamic Interactions of the Ovarian-Fallopian Axis in High Grade Serous Ovarian Cancer | University of Illinois, Chicago, IL |
Vickie Wysocki; Native Mass Spectrometry Guided Structural Biology Center; | Georgia Tech University, Atlanta, GA |
Yen-Yu Ian Shih; SORDINO-fMRI for Mouse Brain Applications; | UNC Chapel Hill, Chapel Hill, NC |
Shilpa Buch; HIV Tat and Opiate-mediated aberrations in glial-neuronal crosstalk: Implications for the role of extracellular RNA in HAND. | University of Nebraska Medical Center, Omaha, NE |
Paul DeAngelis; Development of solid-state nanopore technology for improved glycosaminoglycan analytics; | University of Oklahoma Health Sciences, Oklahoma City, OK |
Table 2. Continuing and new Collaborative Projects
PI/Project Title | Affiliations |
Prof. A. Godwin Exosomes characterization in Ovarian Cancer | KUMC, Kansas City, KS |
Dr. A. Baird Integrated system for EVs analysis for Stroke diagnostic | SUNY Downstate Medical Center, New York City, NY |
Mark Oldakowski Commercialization of X-ToF sequencer for DNA | Bionano, Co, San Diego CA |
Kambez Benam Building Plastic MPS using Injection Molding | University of Pittsburgh, Pittsburg, PA |
Jeanne Norton Extrusion of COC 8007 | Pittsburg State University, Pittsburg, KS |
Kim Ritola AAV status determination using RPS | UNC-Chapel Hill, NC |
Kyoto Watanabe Generating Plastic Chips for Electrophoresis | Shimadzu Corporation, Somerset, NJ |
Jane McKeating Surface Immobilization of XRN1 on Plastic Beads | University of Oxford, Oxford, UK |
Jared Magoline Patterning Nanostructures using Ion-Beam Free Methods | Teraprint, Chicago, IL |
Gerson Aguirre Plastic Nanofluidic chip for DNA stretching | Bionano, San Diego, CA |
Dr. Taylor; Dr. Weir, Evs as a marker of bladder cancer | KUMC, Kansas City, KS |
Dr. Navneet Dillon, EV in neurological disorders | KUMC, Kansas City, KS |
Dr. Shane Stecklein, EV miR sequencing for TNBC predicting treatment. | KUMC, Kansas City, KS |
Dr. Frank Barrone, Modelling stroke in animal models | SUNY Downstate, New York City, NY |
Dr. Rolf Muller Integrated system for selection/enumeration of VPs | BioFludica, San Diego, CA |
Table 3. Past Collaborative Projects.
PI/Project Title | Affiliation |
Dr. G. Gan Isolation of CTCs from blood of head and neck squamous cell carcinoma (HNSCC) patients | KUMC, Kansas City,KS |
Dr. Muller /Prof. Godwin/Prof. Soper/Dr. G. Gan SARS CoV-2 Viral Particle Detection in patients hospitalized with COVID-19 | Biofluidica, San Diego, CA |
Dr. Belinda Sturm Viral particles Isolation from Wastewaters | KU, Lawrence, KS |
John Callahan, Sequencing bacterial pathogens at the point-of-use (POU). | Food and Drug Administration, Washington, DC |
Daniel Chiu, Digital PCR Quantification of BCR-ABL for CML Diagnosis and Monitoring in a LMIC Setting. | University of Washington, Seattle, WA |
Heather Desaire, Development of a Rapid Glycosylation Profiling System using Mass Spectrometry Data. | University of Kansas, Lawrence, KS |
Subrajit Saha, Progenitor Cell Based Therapy to Mitigate Radiation Induced Gastrointestinal Syndrome. | KU Medical Center, Kansas City, KS |
Marc Porter, Field Deployable Platform for Prognostic Hepatic Cancer Screening in Low-Resource Settings. | University of Utah, Salt Lake City, UT |
Bruce Gale, High Throughput Fabrication of Nanopore Devices. | University of Utah, Salt Lake City, UT |
Sean Ford, Jeff Reifenberger, Mark Oldakowski –High Throughput Manufacturing of Saphyr ChipTM | Bionano Genomics, San Diego, CA. |
Aaron Nagel, Searching for RNA Modifications. | Digital NanoGenetics, Lawrence, KS. |
Keith August, Minimal Residual Disease (MRD) Monitoring using Peripheral Blood in Pediatric Patients with Acute Lymphoblastic Leukemia (ALL, T and B-type). | Children’s Mercy Hospital, Kansas City, MO. |
Dr. Victor Manneh, Modification of the surface of thermoplastics | Xen Biofluidx Inc., San Diego, CA |
Lisa Podlaha-Murphy, Building highly durable mixed-scale electroformed molding tools. | Clarkson University, Potsdam, NY |
Alan Hamersley, High-scale production of nanometer structures using injection molding. | Technicolor, Los Angeles, CA |
Blake Peterson, Rich Givens Photocleavable Linkers for Exosomes Release. | University of Kansas, Lawrence, KS |
Manas Gartia. Nanofluidic plasmonic sensors. | Louisiana State University, Baton Rouge, LA |
TJ Cradick, MPS for CRISPR Validation. | CRISPR Technologies, Cambridge, MA |
David Greenhalgh. Nam K Mixed scale fluidic systems for the detection and characterization of the role and presence of bacteria during wound/burn healing. | Shriner’s Hospital for Children, Sacramento, CA, UC Davis Pathology & Laboratory Med, Davis, CA. |
Taehyun Park, Kyungnam PABP Thermofusion Bonding of High Tg Polymers. | ULSAN University, Ulsan, South Korea. |
Anup Kasi, Circulating tumor cells as a potential biomarker in Colon and Appendiceal cancers with peritoneal metastasis. Funded by | KU Cancer Center Kansas City, KS. |
Priyanka Sharma, Evaluation of longitudinal ctDNA to elucidate markers of response and acquired drug resistance to PI3K inhibitor therapy. | KU Cancer Center, Kansas City, KS. |
Wen Jin Meng, Double-Punch Molding in Aluminum. | Louisiana State University, Baton Rouge, LA. |
Tara Lin, Acute Myeloid Leukemia (AML) Circulating Leukemia Cells with Cancer Stem Cell Like Properties. | KUMC and KU NCI Designated Cancer Center, Kansas City, KS. |
Matt Hupert, Integrated Systems for the Analysis of Circulating Multiple Myeloma Cells. | BioFluidica, Chapel Hill, NC |
George Martin, Terry Fetterhoff – ROCHE, Pleasanton, CA. Selection of CTC Orthogonal subpopulations. | ROCHE, Pleasanton, CA. |
Lisa Carey, Enumeration of CTCs in metastatic breast cancer patients. | University of North Carolina LCCC, Chapel Hill, NC. |
Young Whang, Enumeration of CTC in CRPC Patients. | University of North Carolina LCCC, Chapel Hill, NC |
Peter Voorhees, Analysis of CMMC for the Diagnosis of Multiple Myeloma. | University of North Carolina School of Medicine, Chapel Hill, NC. |
Elizabeth Podlaha-Murphy, XTOF – A New Platform for High Speed Sequencing of Single DNA Molecules. | Northeastern University, Boston, MA |
Tom Albert, Nanosensors for High Throughput Sequencing. | ROCHE Diagnostics, Pleasanton, CA |
JaeJong Lee, Molding/Demolding Technologies. | Korea Institute of Machinery & Materials, Daejeon, South Korea. |
Seok-Yong Lee, Structure, Function, and Pharmacology of Neuronal Membrane Transport Proteins. | Duke University, Durham, NC. |
Rolf Muller, KUMC, Exosomes Isolation from Plasma of Breast Cancer Patients | Biofluidica, San Diego, CA |
Rolf Muller, Isolation of cfDNA from Clinical Samples | Biofluidica, San Diego, CA |
Prof. Paul Herring, Injection molding of thermoplastics | Pittsburg State University, Pittsburg, KS |
Dr. Maria Bauer, Patterning Thin Film Conductors on Plastic Sheets | Stratec Consumables, Anif, Austria |
Service Projects
Table 1. Phase 3 NEW Service Projects
PI/Project Title | Funding |
Paul DeAngelis; University of Oklahoma Health Sciences, Oklahoma City,OK; Development of solid-state nanopore technology for improved glycosaminoglycan analytics; | National Institutes of Health; R01 GM134226; |
Dr. Neda Barjesteh and Dr. Stephane Shu Kin So (Director, External Innovation); Isolation of cfDNA and EVs from animal samples. Zoetis; Kalamazoo, MI; www.zoetis.com; | Corporate R&D funding; |
Alex Hyler (PI); CytoRecovery; Blacksburg, VA; Microfluidic chips for the biophysical isolation of rare cells | Internal R&D funding |
Jean-Luc Fraikin (PI); Spectradyne, Signal Hill, CA; Generating a production path for the Spectradyne consumable chip for RPS | Corporate R&D funding |
Anthony Atala/Sean Murphy; Wake Forest University School of Medicine, Winston-Salem, NC; Human Organ Tissue Equivalent Models of Fibrosing Chemical Exposure to Bridge Preclinical and Clinical Translation of Medical Countermeasures; | Office of Assistant Secretary for Preparedness and Response/Biomedical Advanced Research and Development Authority (BARDA) |
James Keck (PI): University of Wisconsin, Madison; Generation of Fusion Proteins For DNA Repair | 2RM1GM130450 |
Greg Cooksey (PI); National Institute of Standards and Technology; Gaithersburg, MD Plastic-based microfluidic chips for the analysis of single cells using flow cytometry | NIST R&D Funding |
David Issadore (PI); University of Pennsylvania – High Throughput Digital Droplet Assays for Ultrasensitive Multimodal (DNA, RNA, and Protein) Diagnostic | R33CA287135 |
Susanta Hui (PI); City of Hope, Duarte, CA; Myeloid cell-selective, oligonucleotide-based STAT3 inhibition combined with total marrow and lymphoid irradiation for immunotherapy of acute myeloid leukemia | 5R01CA284593-02 |
Greg Studdard, BioFluidica, Durham, NC; New chip for the sorting of EVs in a label-free fashion | Corporate R&D funding |
Table 2. Continuing and new additional Service Projects.
PI/Project Title | Affiliations |
Prof. Joanna Burdette Selection of ovarian cancer associated EVs | University of Illinois, Chicago, Il |
Prof. Martin, Scott Fabrication of Microfluidic Molds | Univ. of St. Louis, St. Louis, MO |
Prof. John McDevitt Development of plastic chips for oral cancer diagnostics | Oraliva New York, NY |
Prof. Aaron Timperman Fabrication and molding of structures for An Integrated Microfluidic System for Combining Top-Down and Bottom-Up Proteomics | University of Illinois, Urbana-Champaign, IL |
Prof. Jason Springer Development of a chip-based analytical platform to enable point-of-care monitoring of peripheral rituximab levels. | Vanderbilt University Medical Center, Nashville, TN |
Prof. Vivien Coulson-Thomas Age-related changes in HA in the context of Meibomian gland dysfunction. | College of Optometry, University of Houston, Houston, TX |
Prof. Francesca E. Duncan Analysis of follicular fluid HA size distribution to probe the role of matrix degradation on oocyte expansion in reproductive aging in humans. | Feinberg School of Medicine, Northwestern University, Boston, MA |
Prof. Kelley, S. O. Tumor Cell Isolation | Cellular Analytics, Toronto, Canada. |
Dr. Julie Hakim Nanopore analysis of hyaluronan size distribution. | Baylor College of Medicine, Waco, TX |
Dr. Aguirre Gerson,Building Plastic Devices for DNA Stretching | BionanoGenomics, San Diego, CA. |
Try Shoop, Generating new plastics for high process yield rate of nanofluidic devices | Polyplastics USA, Inc., Farmington Hills MI |
Dave Alberty, Processing large sample volumes for isolation of EVs | InnovaPrep, Drexel, MO |
Prof. Kambez Benam, Building plastic MPS using injection molding | University of Colorado, Boulder, CO |
Dr. Stavros Garantziotis, Nanopore analysis of HA size distribution | National Institute of Environmental health Sciences, Durham, NC |
Table 3. Completed Past Service Projects.
PI/Project Title | Affiliation |
Prof. Pulliam, Lynn, Brain-derived exosomes as blood markers of HIV cognitive impairment. | Northern California Institute Research & Education, San Francisco, CA |
Dr. Kasi, Anup MD , Circulating Tumor Cells for integrating PARP inhibitors in DNA repair-deficient Pancreatic Cancers | KU Medical Center, Kansas City, KS. |
Dr. Kasi, KU Medical Center, Kansas City, KS, CTC isolation in met PDAC patients enrolled in NIRA-PANC clinical trial. | KU Medical Center, Kansas City, KS. |
Dr. Yipeng Wang Isolation of Extracellular Vesicles with PSMA antigen for Prostate Cancer Management. | Spanish National Cancer Research Center, Madrid, Spain. |
Dr. Hyler, Alex Microfluidic chips for the biophysical isolation of rare cells | CytoRecovery (Blacksburg, VA) |
Prof. Dominique de Kleijn, and Dr. Egbert Smit Evaluation of suitability of affinity chip for PERSUASIVE's EV analytical and clinical diagnostic workflow. | Persuasive Dx, UMC Utrecht, The Netherlands, Europe |
Prof. Polineni, Deepika MD Nasal Lavage Exosome Analysis Specifies Therapeutic Targets for Precision Treatment in Cystic Fibrosis. | KU Medical Center, Kansas City, KS. |
Dr. Morris, Jill K.Exosomes characterization in Alzheimer | KU Medical Center, Kansas City, KS. |
Prof. Sharma, Priyanka Evaluation of longitudinal ctDNA to elucidate markers of response and acquired drug resistance | KU Medical Center, Kansas City, KS. |
Dr. Funk, Ryan Development of chip-based assay for the quantitation of molecular markers of MTX response in autoimmune arthritis | KU Medical Center, Kansas City, KS |
Dr. Ford, Shawn | Bionano, Co. San Diego, CA |
Prof. Heungjoo Shin, Development of a Multiplex Biosensor Array Chip Passed on Stacked Triple Carbon Nano-electrode Sets for the Early Diagnosis of Myocardial Infarction and Glucose Monitoring. | UNIST (Ulsan National Institute of Science & Technology) |
Prof. Hatim Husain/ Rolf Muller, CTC in Lung Cancer | Biofluidica, Inc |
Prof.Ganguly, Sid Isolation of CPC from Blood of Patients Diagnosed with Plasma Cell Disorders. | KU Medical Center, Kansas City, KS |
Prof.Armistead, Paul, Isolation of AML CLC | UNC Chapel Hill |
Prof.Bae-Jump, Victoria, Isolation of CTC in Epithelial Ovarian Cancer | UNC Chapel Hill |
Prof. Jarrod A. Marto Fabrication of plastic chips via injection molding | Dana Farber Cancer Institute, MA |
Dr. Teddy de Groot Fabrication of metal mold | LevitasBio, CA |
Dr. Vivien Coulson Thomas Nanopore analysis of hyaluronan size distribution | University of Houston. |
Dr. Francesca Duncan Nanopore analysis of hyaluronan size distribution. | Northwestern University |
Dr. Steven P. Jones Nanopore analysis of hyaluronan size distribution. | University of Louisville |
Dr. Larry Sherman Nanopore analysis of hyaluronan size distribution. | Oregon Health & Science University |
Dr. Oliver Porquie Nanopore analysis of hyaluronan size distribution. | Harvard Medical School |
Dr. Rebecca Wells Nanopore analysis of hyaluronan size distribution. | University of Pennsylvania |
Dr. Michele T. Pritchard Nanopore analysis of hyaluronan size distribution. | University of Kansas Medical Center |
Dr. Sabina Hrabetova Nanopore analysis of hyaluronan size distribution. | SUNY Downstate Health Sciences University |
Dr. Jennifer Curtis Nanopore analysis of hyaluronan size distribution. | Georgia Tech |
Dr. Arthur Beaudet Fetal Cell Capture from Blood of Pregnant Women. | Luna Genetics, TX |
Prof.Keith August, Circulating Leukemic Cells Detection in B-Cell ALL. | Children’s Mercy Hospital, Kansas City, MO. |
Dr. Don Owens Nanopore analysis of hyaluronan size distribution. | TFF Pharmaceuticals, Foxboro, MA |
Greg Gan, Isolation of CTCs from blood of head and neck squamous cell carcinoma (HNSCC) patients | KU Medical Center, Kansas City, KS. |
Prof. Ashleigh Theberge Injection Molding of Microstructures | University of Washington, Seattle, WA |
Prof. Jen Jen Ye, CTC in PDAC | UNC Chapel Hill |
Prof. Charles Perou, CTC in Breast Cancer | UNC Chapel Hill |
Matt Milowski, CTC in CRPC | UNC Chapel Hill |
Prof. Victoria Bae-Jump,. Circulating Tumor Cells in Endometrial Cancer Patients. | University of North Carolina, Chapel Hill, NC |
Prof. Vinod Dasa and Jeffery Hobden,. Microfluidics for the Analysis of Bacterial Pathogens. | LSU HSC, New Orleans, LA |
Prof. Deok-ho Kim, Development of 3D Cell Culture Surfaces. | University of Washington, Seattle, WA, |
Prof. In-Hyouk Song, Development of Device for Bacterial Cells Isolation. | Texas State University, San Marcos, TX |
Prof. Dorel Moldovan and Dimitris Nikitopoulos, MD Simulations of Transport in Nano-confined Environments. | LSU, Baton Rouge, LA |
Prof. Kidong Park, Developing roll-to-roll process for cell culture substrate. | LSU, Baton Rouge, LA. |
Dr. Margaret Gulley, Cell-free DNA in blood from cancer patients. | University of North Carolina, Chapel Hill, NC. |
Dr. Gerard J. Oakley III,. Phase 1b/2 Study of Olaratumab plus Doxorubicin in Soft Tissue Sarcoma (STS) Using CTCs as a Companion Biomarker. | Eli Lilly and Company, Indianapolis, IN |
Prof. Susan Lunte, Microfluidic Methods for Measurement of Mitochondrial Biomarkers of Alzheimer’s disease. | University of Kansas, Lawrence, KS. |
Prof. Linheng Li, Hematopoietic Stem Cell Isolation. | Stowers Institute for Medical Research, Kansas City, MO. |
